Protease-activated Receptor-1 Down-regulation

1 Down - regulation of Protease - activated Receptor - 1 Is Regulated by Sorting

Granzyme K Activates Protease-Activated Receptor-1

Granzyme K (GrK) is a trypsin-like serine protease that is elevated in patients with sepsis and acute lung inflammation. While GrK was originally believed to function exclusively as a pro-apoptotic protease, recent studies now suggest that GrK may possess other non-cytotoxic functions. In the context of acute lung inflammation, we hypothesized that GrK induces pro-inflammatory cytokine release ...

Protease-activated receptor-2 modulates protease-activated receptor-1-driven neointimal hyperplasia.

OBJECTIVE Emerging evidence suggests that protease-activated receptors-1 and -2 (PAR1 and PAR2) can signal together in response to proteases found in the rapidly changing microenvironment of damaged blood vessels. However, it is unknown whether PAR1 and PAR2 promote or mitigate the hyperplastic response to arterial injury. Using cell-penetrating PAR1 pepducins and mice deficient in PAR1 or PAR2...

Immune regulation of protease-activated receptor-1 expression in murine small intestine during Nippostrongylus brasiliensis infection.

Infection with gastrointestinal nematodes exerts profound effects on both immune and physiological responses of the host. Helminth infection induces a hypercontractility of intestinal smooth muscle that is dependent on the Th2 cytokines, IL-4 and IL-13, and may contribute to worm expulsion. Protease-activated receptors (PARs) are expressed throughout the gut, and activation of PAR-1 was observe...

Clathrin-dependent Internalization of Protease-activated Receptor-1: Regulation by Ubiquitination and Epsin

Breann Louise Wolfe Clathrin-dependent Internalization of Protease-activated Receptor-1: Regulation by Ubiquitination and Epsin (Under the direction of Dr. JoAnn Trejo) Thrombin, the main effector protease of the coagulation cascade elicits its cellular effects via activation of a family of G-protein coupled receptors (GPCRs) called proteaseactivated receptors (PARs). PAR1, the prototype of thi...